50 research outputs found
Two-year-olds at elevated risk for ASD can learn novel words from their parents
Education and Child Studie
Diagnosing selective mutism: a critical review of measures for clinical practice and research
Education and Child Studie
Is It Fear?: Similar brain responses to fearful and neutral faces in infants with a heightened likelihood for autism spectrum disorder
Education and Child Studie
More on clinical and computed tomography characteristics of COVID-19 associated acute pulmonary embolism
Perioperative Medicine: Efficacy, Safety and Outcome (Anesthesiology/Intensive Care
Electronic structure and magnetism of Mn doped GaN
Mn doped semiconductors are extremely interesting systems due to their novel
magnetic properties suitable for the spintronics applications. It has been
shown recently by both theory and experiment that Mn doped GaN systems have a
very high Curie temperature compared to that of Mn doped GaAs systems. To
understand the electronic and magnetic properties, we have studied Mn doped GaN
system in detail by a first principles plane wave method. We show here the
effect of varying Mn concentration on the electronic and magnetic properties.
For dilute Mn concentration, states of Mn form an impurity band completely
separated from the valence band states of the host GaN. This is in contrast to
the Mn doped GaAs system where Mn states in the gap lie very close to the
valence band edge and hybridizes strongly with the delocalized valence band
states.
To study the effects of electron correlation, LSDA+U calculations have been
performed.
Calculated exchange interaction in (Mn,Ga)N is short ranged in contrary to
that in (Mn,Ga)As where the strength of the ferromagnetic coupling between Mn
spins is not decreased substantially for large Mn-Mn separation. Also, the
exchange interactions are anisotropic in different crystallographic directions
due to the presence or absence of connectivity between Mn atoms through As
bonds.Comment: 6 figures, submitted to Phys. Rev.
Early effects of unfractionated heparin on clinical and radiological signs and D-dimer levels in patients with COVID-19 associated pulmonary embolism: an observational cohort study
Perioperative Medicine: Efficacy, Safety and Outcome (Anesthesiology/Intensive Care
Risk of thrombotic complications in influenza versus COVID-19 hospitalized patients
Background: Whereas accumulating studies on patients with coronavirus disease 2019 (COVID-19) report high incidences of thrombotic complications, large studies on clinically relevant thrombosis in patients with other respiratory tract infections are lacking. How this high risk in COVID-19 patients compares to those observed in hospitalized patients with other viral pneumonias such as influenza is unknown.Objectives: To assess the incidence of venous and arterial thrombotic complications in hospitalized patients with influenza as opposed to that observed in hospitalized patients with COVID-19.Methods: This was a retrospective cohort study; we used data from Statistics Netherlands (study period: 2018) on thrombotic complications in hospitalized patients with influenza. In parallel, we assessed the cumulative incidence of thrombotic complications-adjusted for competing risk of death-in patients with COVID-19 in three Dutch hospitals (February 24 to April 26, 2020).Results: Of the 13 217 hospitalized patients with influenza, 437 (3.3%) were diagnosed with thrombotic complications, versus 66 (11%) of the 579 hospitalized patients with COVID-19. The 30-day cumulative incidence of any thrombotic complication in influenza was 11% (95% confidence interval [CI], 9.4-12) versus 25% (95% CI, 18-32) in COVID-19. For venous thrombotic (VTC) complications and arterial thrombotic complications alone, these numbers were, respectively, 3.6% (95% CI, 2.7-4.6) and 7.5% (95% CI, 6.3-8.8) in influenza versus 23% (95% CI, 16-29) and 4.4% (95% CI, 1.9-8.8) in COVID-19.Conclusions: The incidence of thrombotic complications in hospitalized patients with influenza was lower than in hospitalized patients with COVID-19. This difference was mainly driven by a high risk of VTC complications in the patients with COVID-19 admitted to the Intensive Care Unit. Remarkably, patients with influenza were more often diagnosed with arterial thrombotic complications.Perioperative Medicine: Efficacy, Safety and Outcome (Anesthesiology/Intensive Care
Measurement invariance of the Childhood Autism Rating Scale (CARS) across six countries
Education and Child Studie
The impact of the metabotropic glutamate receptor and other gene family interaction networks on autism
Although multiple reports show that defective genetic networks underlie the aetiology of autism, few have translated into pharmacotherapeutic opportunities. Since drugs compete with endogenous small molecules for protein binding, many successful drugs target large gene families with multiple drug binding sites. Here we search for defective gene family interaction networks (GFINs) in 6,742 patients with the ASDs relative to 12,544 neurologically normal controls, to find potentially druggable genetic targets. We find significant enrichment of structural defects (P≤2.40E-09, 1.8-fold enrichment) in the metabotropic glutamate receptor (GRM) GFIN, previously observed to impact attention deficit hyperactivity disorder (ADHD) and schizophrenia. Also, the MXD-MYC-MAX network of genes, previously implicated in cancer, is significantly enriched (P≤3.83E-23, 2.5-fold enrichment), as is the calmodulin 1 (CALM1) gene interaction network (P≤4.16E-04, 14.4-fold enrichment), which regulates voltage-independent calcium-activated action potentials at the neuronal synapse. We find that multiple defective gene family interactions underlie autism, presenting new translational opportunities to explore for therapeutic interventions